报告题目:Cold and controlled nanoparticle beams for single particle diffractive imaging

报告人：Amit K. Samanta

报告时间：8月25日（周三）17:00

报告地点：腾讯会议https://meeting.tencent.com/dm/i5A5nzpo8j2q 会议 ID：187429140

主办单位：原子与分子物理研究所

报告人简介：

Amit K. Samanta obtained his B.Sc. and M.Sc. degrees in Chemistry from the University of Calcutta, India, and his Ph.D. from the Indian Association for the Cultivation of Science (IACS), India. He worked as a postdoctoral researcher at University of Southern California, USA, during 2011--2016. From 2016, he is working as a research scientist at Deutsches Elektronen-Synchrotron DESY, Germany. Currently, Amit is the team leader for COMOTION project at CFEL, DESY.

摘要：

Single-particle diffractive imaging (SPI) is emerging as a new technique for 3D imaging of aerosolized nanoparticles at x-ray free-electron lasers (XFELs). How- ever, one of the primary bottlenecks in realizing SPI is the efficient delivery of isolated, reproducible target particles into the x-ray focus. Here, I present novel approaches for the production of cold and high density beams of broad variety of biological nanoparticles, ranging from single domain proteins including membrane proteins to multi-subunit protein complexes and molecular machines, designed for use in XFEL experiments. This will also enable us to gain a better understanding of the ultrafast dynamics across extended biological systems. Fast cooling from room temperature to 10 Kelvin in sub 10 microseconds will help freezing phase-space distribution, enhancing rare structures, and even trapping reaction intermediates.